/* Reset and Base Styles */
* {
    margin: 0;
    padding: 0;
    box-sizing: border-box;
}

/* CSS Variables */
:root {
    --primary: 221 83% 53%;
    --primary-foreground: 0 0% 98%;
    --secondary: 210 40% 98%;
    --secondary-foreground: 222.2 84% 4.9%;
    --muted: 210 40% 96%;
    --muted-foreground: 215.4 16.3% 46.9%;
    --accent: 210 40% 94%;
    --accent-foreground: 222.2 84% 4.9%;
    --destructive: 0 84.2% 60.2%;
    --destructive-foreground: 210 40% 98%;
    --border: 214.3 31.8% 91.4%;
    --input: 214.3 31.8% 91.4%;
    --ring: 221 83% 53%;
    --background: 0 0% 100%;
    --foreground: 222.2 84% 4.9%;
    --card: 0 0% 100%;
    --card-foreground: 222.2 84% 4.9%;
    --popover: 0 0% 100%;
    --popover-foreground: 222.2 84% 4.9%;
    --medical-blue: 200 95% 50%;
    --medical-teal: 180 65% 55%;
    --success: 142 71% 45%;
    --warning: 38 92% 50%;
    --info: 200 95% 50%;
    --gradient-primary: linear-gradient(135deg, hsl(var(--primary)), hsl(var(--medical-teal)));
    --shadow-elegant: 0 10px 30px -10px hsl(var(--primary) / 0.3);
    --shadow-glow: 0 0 40px hsl(var(--medical-teal) / 0.4);
    --transition-smooth: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
}

/* Body and Typography */
body {
    font-family: -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, "Helvetica Neue", Arial, sans-serif;
    background-color: hsl(var(--background));
    color: hsl(var(--foreground));
    line-height: 1.6;
}

/* Layout */
.container {
    max-width: 1200px;
    margin: 0 auto;
    padding: 2rem;
}

/* Header */
.header {
    text-align: center;
    margin-bottom: 3rem;
}

.header h1 {
    font-size: 2.5rem;
    font-weight: bold;
    background: var(--gradient-primary);
    -webkit-background-clip: text;
    background-clip: text;
    color: transparent;
    margin-bottom: 0.5rem;
}

.header p {
    color: hsl(var(--muted-foreground));
    font-size: 1.1rem;
}

/* Card Component */
.card {
    background: hsl(var(--card));
    border: 1px solid hsl(var(--border));
    border-radius: 12px;
    padding: 2rem;
    margin-bottom: 2rem;
    box-shadow: var(--shadow-elegant);
    transition: var(--transition-smooth);
    opacity: 1;
}

.card.active {
    border-color: hsl(var(--primary));
    box-shadow: var(--shadow-glow);
}

.card.fade-out {
    opacity: 0;
}

.card.fade-in {
    animation: fadeIn 0.3s ease forwards;
}

.result-card {
    animation: fadeIn 0.5s ease-in;
}

/* Card Header */
.card-header {
    margin-bottom: 1.5rem;
    padding-bottom: 1rem;
    border-bottom: 1px solid hsl(var(--border));
}

.card-title {
    font-size: 1.5rem;
    font-weight: 600;
    color: hsl(var(--foreground));
    display: flex;
    align-items: center;
    gap: 0.5rem;
}

/* Form Elements */
.form-group {
    margin-bottom: 1.5rem;
}

.form-label {
    display: flex;
    align-items: center;
    gap: 0.5rem;
    font-weight: 500;
    margin-bottom: 0.5rem;
    color: hsl(var(--foreground));
}

.required {
    color: hsl(var(--destructive));
}

.form-description {
    color: hsl(var(--muted-foreground));
    font-size: 0.9rem;
    margin-bottom: 1rem;
}

.input, .select, .textarea {
    width: 100%;
    padding: 0.75rem 1rem;
    border: 1px solid hsl(var(--border));
    border-radius: 8px;
    background: hsl(var(--background));
    color: hsl(var(--foreground));
    font-size: 1rem;
    transition: var(--transition-smooth);
}

.input:focus, .select:focus, .textarea:focus {
    outline: none;
    border-color: hsl(var(--ring));
    box-shadow: 0 0 0 2px hsl(var(--ring) / 0.2);
}

.input.invalid {
    border-color: hsl(var(--destructive));
}

.validation-message {
    color: hsl(var(--destructive));
    font-size: 0.875rem;
    margin-top: 0.25rem;
    display: none;
}

.validation-message.show {
    display: block;
}

.radio-group {
    display: flex;
    flex-direction: column;
    gap: 0.75rem;
}

.radio-option {
    display: flex;
    align-items: center;
    gap: 0.75rem;
    padding: 0.75rem;
    border: 1px solid hsl(var(--border));
    border-radius: 8px;
    cursor: pointer;
    transition: var(--transition-smooth);
}

.radio-option:hover {
    background: hsl(var(--accent));
    transform: translateY(-2px);
}

.radio-option input[type="radio"] {
    margin: 0;
}

.radio-option.selected {
    background: hsl(var(--primary) / 0.1);
    border-color: hsl(var(--primary));
    transform: translateY(-2px);
}

/* Buttons */
.button {
    display: inline-flex;
    align-items: center;
    justify-content: center;
    gap: 0.5rem;
    padding: 0.75rem 1.5rem;
    border: none;
    border-radius: 8px;
    font-size: 1rem;
    font-weight: 500;
    cursor: pointer;
    transition: var(--transition-smooth);
    text-decoration: none;
}

.button-primary {
    background: hsl(var(--primary));
    color: hsl(var(--primary-foreground));
}

.button-primary:hover {
    background: hsl(var(--primary) / 0.9);
    box-shadow: var(--shadow-glow);
    transform: translateY(-2px);
}

.button-secondary {
    background: hsl(var(--secondary));
    color: hsl(var(--secondary-foreground));
}

.button-secondary:hover {
    background: hsl(var(--secondary) / 0.8);
    transform: translateY(-2px);
}

.button-outline {
    background: transparent;
    color: hsl(var(--foreground));
    border: 1px solid hsl(var(--border));
}

.button-outline:hover {
    background: hsl(var(--accent));
    transform: translateY(-2px);
}

.button:disabled {
    opacity: 0.5;
    cursor: not-allowed;
    transform: none;
}

/* Navigation */
.navigation {
    display: flex;
    justify-content: space-between;
    align-items: center;
    margin-top: 2rem;
    padding-top: 1.5rem;
    border-top: 1px solid hsl(var(--border));
}

/* Progress Bar */
.progress-bar {
    width: 100%;
    height: 8px;
    background: hsl(var(--muted));
    border-radius: 4px;
    margin-bottom: 2rem;
    overflow: hidden;
}

.progress-fill {
    height: 100%;
    background: var(--gradient-primary);
    transition: width 0.5s cubic-bezier(0.4, 0, 0.2, 1);
}

/* Tooltips */
.info-tooltip {
    position: relative;
    display: inline-block;
    cursor: help;
}

.info-icon {
    width: 18px;
    height: 18px;
    border-radius: 50%;
    background: hsl(var(--info));
    color: white;
    display: flex;
    align-items: center;
    justify-content: center;
    font-size: 12px;
    font-weight: bold;
    transition: var(--transition-smooth);
}

.info-icon:hover {
    transform: scale(1.2);
}

.tooltip-content {
    position: absolute;
    bottom: 125%;
    left: 50%;
    transform: translateX(-50%) scale(0.8);
    background: hsl(var(--popover));
    color: hsl(var(--popover-foreground));
    padding: 1rem;
    border-radius: 8px;
    box-shadow: 0 4px 12px rgba(0, 0, 0, 0.15);
    width: 300px;
    z-index: 1000;
    opacity: 0;
    visibility: hidden;
    transition: opacity 0.3s, transform 0.3s;
    border: 1px solid hsl(var(--border));
}

.info-tooltip:hover .tooltip-content {
    opacity: 1;
    visibility: visible;
    transform: translateX(-50%) scale(1);
}

.tooltip-content::after {
    content: '';
    position: absolute;
    top: 100%;
    left: 50%;
    transform: translateX(-50%);
    border: 6px solid transparent;
    border-top-color: hsl(var(--popover));
}

.tooltip-title {
    font-weight: 600;
    margin-bottom: 0.5rem;
}

/* Criteria Summary */
.criteria-summary {
    margin-bottom: 2rem;
}

.summary-toggle {
    background: hsl(var(--secondary));
    color: hsl(var(--secondary-foreground));
    border: 1px solid hsl(var(--border));
    padding: 0.5rem 1rem;
    border-radius: 8px;
    cursor: pointer;
    font-size: 1rem;
    transition: var(--transition-smooth);
}

.summary-toggle:hover {
    background: hsl(var(--primary) / 0.1);
    border-color: hsl(var(--primary));
}

.summary-content {
    background: hsl(var(--card));
    border: 1px solid hsl(var(--border));
    border-radius: 8px;
    padding: 1rem;
    margin-top: 1rem;
    box-shadow: var(--shadow-elegant);
}

/* Results Section */
.results-section {
    background: hsl(var(--card));
    border-radius: 12px;
    padding: 2rem;
    margin-top: 2rem;
    animation: fadeIn 0.5s ease-in;
}

.result-header {
    position: relative;
    margin-bottom: 1.5rem;
    text-align: center;
}

.close-button {
    position: absolute;
    top: 0;
    right: 0;
    background: none;
    border: none;
    font-size: 1.5rem;
    cursor: pointer;
    color: hsl(var(--destructive));
    transition: var(--transition-smooth);
}

.close-button:hover {
    color: hsl(var(--destructive) / 0.8);
}

.classification-badge {
    display: inline-block;
    padding: 0.75rem 1.5rem;
    border-radius: 6px;
    font-weight: 600;
    font-size: 1.3rem;
    text-align: center;
    transition: var(--transition-smooth);
    width: auto;
    margin: 0 auto 1rem;
    animation: scaleIn 0.5s ease;
}

.classification-badge:hover {
    transform: scale(1.05);
}

.classification-badge[data-class="Pathogenic"] {
    background: hsl(var(--destructive) / 0.1);
    color: hsl(var(--destructive));
    border: 1px solid hsl(var(--destructive) / 0.3);
}

.classification-badge[data-class="Likely Pathogenic"] {
    background: hsl(38 100% 50% / 0.1);
    color: hsl(38 100% 35%);
    border: 1px solid hsl(38 100% 50% / 0.3);
}

.classification-badge[data-class="VUS"] {
    background: hsl(var(--warning) / 0.1);
    color: hsl(var(--warning));
    border: 1px solid hsl(var(--warning) / 0.3);
}

.classification-badge[data-class="Likely Benign"] {
    background: hsl(var(--success) / 0.1);
    color: hsl(var(--success));
    border: 1px solid hsl(var(--success) / 0.3);
}

.classification-badge[data-class="Benign"] {
    background: hsl(var(--success) / 0.15);
    color: hsl(var(--success));
    border: 1px solid hsl(var(--success) / 0.4);
}

.result-content {
    display: flex;
    flex-direction: column;
    gap: 1.5rem;
}

.evidence-summary {
    display: grid;
    grid-template-columns: 1fr 1fr;
    gap: 2rem;
}

.pathogenic-evidence, .benign-evidence {
    background: hsl(var(--secondary));
    border-radius: 12px;
    padding: 1.5rem;
    box-shadow: var(--shadow-elegant);
    animation: slideInLeft 0.5s ease-in;
}

.benign-evidence {
    animation: slideInRight 0.5s ease-in;
}

.evidence-table {
    width: 100%;
    border-collapse: collapse;
}

.evidence-table tr {
    border-bottom: 1px solid hsl(var(--border));
}

.evidence-table td {
    padding: 0.5rem 0;
    transition: color 0.3s ease;
}

.evidence-table td:nth-child(2) {
    text-align: right;
    font-weight: bold;
}

.evidence-table tr:last-child {
    border-bottom: none;
}

.strength-bar {
    position: relative;
    margin-top: 1rem;
    height: 30px;
    background: hsl(var(--muted));
    border-radius: 15px;
    overflow: hidden;
    color: white;
    font-weight: bold;
    display: flex;
    align-items: center;
    justify-content: center;
}

.strength-bar .bar-fill {
    position: absolute;
    left: 0;
    top: 0;
    height: 100%;
    width: 0;
    transition: width 1s ease-in-out;
}

.strength-bar .bar-text {
    position: relative;
    z-index: 1;
}

.strength-bar.pathogenic .bar-fill {
    background: hsl(var(--destructive));
}

.strength-bar.benign .bar-fill {
    background: hsl(var(--success));
}

.criteria-details {
    background: hsl(var(--card));
    border-radius: 12px;
    padding: 1.5rem;
    box-shadow: var(--shadow-elegant);
    animation: fadeInUp 0.5s ease-in;
}

.evidence-list {
    list-style: none;
    padding-left: 0;
}

.evidence-item {
    display: flex;
    justify-content: space-between;
    align-items: center;
    padding: 0.5rem 0;
    border-bottom: 1px solid hsl(var(--border));
    transition: var(--transition-smooth);
}

.evidence-item:hover {
    background: hsl(var(--accent));
    transform: translateX(5px);
}

.evidence-item:last-child {
    border-bottom: none;
}

.evidence-tag {
    font-weight: 600;
    color: hsl(var(--primary));
}

.evidence-score {
    background: hsl(var(--muted));
    color: hsl(var(--muted-foreground));
    padding: 0.25rem 0.5rem;
    border-radius: 4px;
    font-size: 0.875rem;
}

/* Loading Spinner */
.loading-spinner {
    display: flex;
    flex-direction: column;
    align-items: center;
    justify-content: center;
    padding: 2rem;
}

.spinner {
    border: 4px solid hsl(var(--muted));
    border-top: 4px solid hsl(var(--primary));
    border-radius: 50%;
    width: 40px;
    height: 40px;
    animation: spin 1s linear infinite;
}

@keyframes spin {
    0% { transform: rotate(0deg); }
    100% { transform: rotate(360deg); }
}

/* External Links */
.external-links {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(150px, 1fr));
    gap: 1rem;
    margin: 2rem 0;
}

.external-link {
    display: flex;
    align-items: center;
    gap: 0.5rem;
    padding: 0.75rem 1rem;
    background: hsl(var(--accent));
    border: 1px solid hsl(var(--border));
    border-radius: 8px;
    text-decoration: none;
    color: hsl(var(--foreground));
    transition: var(--transition-smooth);
}

.external-link:hover {
    background: hsl(var(--primary) / 0.1);
    border-color: hsl(var(--primary));
    transform: translateY(-2px);
}

/* Resources Section */
.resources-references {
    margin-top: 2rem;
    padding-top: 1.5rem;
    border-top: 1px solid hsl(var(--border));
}

.resources-references h4 {
    margin-bottom: 1rem;
}

.literature-search .input {
    margin-top: 0.5rem;
}

/* Animations */
@keyframes fadeIn {
    from { opacity: 0; }
    to { opacity: 1; }
}

@keyframes fadeInUp {
    from { opacity: 0; transform: translateY(20px); }
    to { opacity: 1; transform: translateY(0); }
}

@keyframes scaleIn {
    from { transform: scale(0.8); opacity: 0; }
    to { transform: scale(1); opacity: 1; }
}

@keyframes slideInLeft {
    from { opacity: 0; transform: translateX(-20px); }
    to { opacity: 1; transform: translateX(0); }
}

@keyframes slideInRight {
    from { opacity: 0; transform: translateX(20px); }
    to { opacity: 1; transform: translateX(0); }
}

/* Utility Classes */
.hidden {
    display: none;
}

.step-indicator {
    text-align: center;
    margin-bottom: 1rem;
    color: hsl(var(--muted-foreground));
}

/* Responsive Design */
@media (max-width: 768px) {
    .container {
        padding: 1rem;
    }

    .header h1 {
        font-size: 2rem;
    }

    .card {
        padding: 1.5rem;
    }

    .evidence-summary {
        grid-template-columns: 1fr;
    }

    .external-links {
        grid-template-columns: 1fr;
    }
}